Protein Arginine Methyltransferase 2 (PRMT2)

Katsanis et al. (1997) isolated HRMT1L1, a novel transcript from chromosome 21 similar to the rat protein arginine N-methyltransferase-1 gene (PRMT1) reported by Lin et al. (1996). Katsanis et al. (1997) found that HRMT1L1 was expressed in all tissues they investigated. Katsanis et al. (1997) noted that the function of protein methyltransferases is posttranslational methylation of arginine residues. Two types of activity had been described, attributed to different classes of enzymes. One methylates myelin protein zero (MPZ); the other was originally thought to methylate histones, but was later found to methylate hnRNPs far more efficiently. The authors suggested that HRMT1L1, a human homolog of yeast RMT1, associates with hnRNPs.