Protein Arginine Methyltransferase 5 (PRMT5)

The S. pombe Shk1 gene is a PAK homolog that is essential for cell viability and that plays key roles in morphologic control and mating response pathways. The Skb1 protein is a regulator of Shk1 that appears to positively modulate Shk1 function. Gilbreth et al. (1996) identified partial cDNAs encoding a human Skb1 homolog. Gilbreth et al. (1998) isolated additional clones corresponding to the complete coding region of human SKB1. The predicted 637-amino acid human protein shares 39% identity with S. pombe Skb1. Independently, Krapivinsky et al. (1998) identified SKB1 as a 72-kD protein that coimmunoprecipitated with the ICln chloride channel and was thus termed IBP72 (ICln-binding protein of 72 kD). Northern blot analysis revealed that the IBP72 gene was widely expressed as a 2.4-kb transcript.