Protein Phosphatase 2, Regulatory Subunit B Gamma (PPP2R2C)

PPP2R2C belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B55 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified. PPP2R2C encodes a deduced 447-amino acid protein that shares 81% and 85% sequence identity with PPP2R2A and PPP2R2B, respectively.