Protein Phosphatase, Mg2+/Mn2+ Dependent 1E (PPM1E)

PPM1E is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase was identified as an interacting protein of Rho guanine nucleotide exchange factors (PIX). PIX proteins are regulators of p21/Cdc42/Rac1-activated kinase 1 (PAK1), a protein kinase mediating biological effects downstream of Rho GTPases. This phosphatase has been shown to block the effects of PAK, and thus inhibit actin stress fiber breakdown and morphological changes driven by cell division cycle 42 (CDC42).Protein phosphatase that inactivates multifunctional CaM kinases such as CAMK4 and CAMK2 May play a role in the inhibition of actin fiber stress breakdown and in morphological changes driven by TNK2/CDC42.