Protein Prenyltransferase Alpha Subunit Repeat Containing Protein 1 (PTaR1)

PTaR1 belongs to the protein prenyltransferase subunit alpha family. Protein prenyltransferases are currently known only in eukaryotes, but they are widespread, being found in vertebrates, insects, nematodes, plants, fungi and protozoa, including several parasites. The chromosomal locations and number of exons from protein prenyltransferase genes in the major eukaryotic model organisms are shown in Table. The α and β subunits have different folds, so are unlikely to have arisen from a common ancestor. Molecular phylogenetic analysis shows that orthologous proteins in different species are more closely related to each other than to their paralogs in the same species; the relationships between the β subunits are not fully clear. As well as the known genes, processed pseudogenes resulting from retrotransposition events have been found in the human and mouse genomes.