Protein Tyrosine Phosphatase, Non Receptor Type 20A (PTPN20A)

Protein tyrosine phosphorylation plays an integral role in cellular signaling and controls diverse cellular responses. Tyrosine phosphorylation is a reversible and dynamic process controlled by the activities of protein tyrosine kinases, which mediate the phosphorylation reaction, and protein tyrosine phosphatases, such as PTPN20A, which catalyze tyrosine dephosphorylation.The most widely expressed variant encodes a deduced 411-amino acid protein with a 280-amino acid PTP catalytic domain containing 10 conserved catalytic motifs. Northern blot analysis detected high expression of a 3.0-kb PTPN20A transcript in testis. RT-PCR detected the primary PTPN20A transcript in all human cell lines examined, whereas the other variants showed more restricted and variable expression.