Pyruvate Dehydrogenase Kinase Isozyme 2 (PDK2)

[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial is an enzyme encoded by the PDK2 gene. It codes for an isozyme of pyruvate dehydrogenase kinase. To find human PDKs, Gudi et al. (1995) used oligonucleotide primers to screen a human liver cDNA library by PCR. The human PDK2 gene encodes a protein with a predicted molecular mass of 46,181 Da that shares 96% identity with that of the rat PDK2 gene. Northern blot analysis showed that the PDK2 message was found in many tissues, with the highest level in heart and skeletal muscle, intermediate levels in brain, kidney, pancreas and liver, and low levels in placenta and lung.