RAB Geranylgeranyltransferase Beta Subunit (RABGGTb)

Rabggtb is ubiquitously expressed in adult mice, but displays a varying pattern of expression during embryonic development. Its expression was detected in whole embryos during early embryonic stages, but was specifically concentrated in the developing brain, heart, and liver during gestation stages E11.5 and E13.5.The cDNA showed 82.4% identity over 341 bp of coding sequence to a rat sequence encoding the catalytic subunit of RAB geranylgeranyl transferase. The amino acid sequences of the 2 genes are 91.1% similar.it encodes a 331-amino acid polypeptide, which is very well conserved among both mammalian and lower eukaryotic species.