RNA Polymerase II Associated Protein 3 (RPAP3)

Jeronimo et al. (2007) identified RPAP3 as an RNA polymerase II-associated protein in HEK293 human embryonic kidney cells and obtained a full-length RPAP3 cDNA by database and sequence analyses. The deduced 665-amino acid protein contains 2 helix-turn-helix tetratricopeptide repeats characteristic of chaperone cofactors.Examination of the protein interaction network revealed that the RPAPs and XAB1 also interacted with components of the Mediator and Integrator complexes, as well as with proteins able to assemble into molecular chaperone complexes, including the prefoldins and the AAA+ ATPases RUVBL1 and RUVBL2.