RNA Polymerase II, DNA Directed Polypeptide H (POLR2H)

The DNA-dependent RNA polymerase II (EC 2.7.7.6) is responsible for the transcription of protein-encoding genes. It is composed of 10 to 14 subunits ranging in mass from approximately 220 kD (POLR2A) to approximately 7 kD (POLR2K;). McKune et al. (1995) showed by immunoprecipitation experiments that both POLR2L and POLR2H are stable and assemble efficiently with yeast RNA pol II. Yeast RPB8 and RPB10 are essential for cell growth and viability. Shpakovski et al. (1995) showed that a human cDNA for POLR2H was able to complement the yeast homolog.McKune et al. (1995) isolated cDNAs corresponding to the genes for POLR2L and POLR2H, the human homologs of S. cerevisiae RPB10 and RPB8, respectively. The POLR2H cDNA encodes a 150-amino acid protein.