Related To Receptor Tyrosine Kinase (RYK)

Ryk is an atypical member of the family of growth factor receptor protein tyrosine kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding domains.This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation in the activation segment. It has been suggested that mediation of biological activity by recruitment of a signaling-competent auxiliary protein may occur through an as yet uncharacterized mechanism. Two alternative splice variants have been identified, encoding distinct isoforms.RYK is composed of three domains, an N-terminal domain, an extracellular ligand binding domain, a transmembrane spanning domain and a C-terminal intracellular domain.