Retinol Dehydrogenase 11 (RDH11)

RHD11, a member of the short-chain dehydrogenase/reductase (SDR) superfamily of oxidoreductases, is expressed at high levels in prostate epithelium, and its expression is regulated by androgens. The deduced protein contains 318 amino acids, and the transcript contains 2 potential polyadenylation signals. RDH11 shares conserved motifs with the SDR family of oxidoreductases, including an N-terminal coenzyme-binding motif, which binds NAD(H) or NADP(H), and a C-terminal catalytic domain. RDH11 shares about 25% sequence identity with other SDR family members. Northern blot and RNA dot blot analyses detected a 2.5-kb transcript expressed at a high level in prostate and at low levels in other tissues, including spleen, thymus, testis, ovary, small intestine, colon, peripheral blood leukocytes, kidney, adrenal gland, and fetal liver.