Retinol Dehydrogenase 14 (RDH14)
Английские синонимы
PAN2; SDR7C4; Short Chain Dehydrogenase/Reductase Family 7C, Member 4; Alcohol dehydrogenase PAN2
Retinoids are chromophores involved in vision, transcriptional regulation, and cellular differentiation. Members of the short chain alcohol dehydrogenase/reductase superfamily catalyze the transformation of retinol to retinal. RDH11-14 could be involved in the first step of all-trans- and 9-cis-retinoic acid production in many tissues. RDH11-14 fill the gap of 11-cis-retinal and all-trans-retinal transformations in photoreceptor (RDH12) and retinal pigment epithelial cells (RDH11).RDH14 transcripts were localized to the photoreceptor IS. RDH14 activity was found to be similar to that of RDH11 and RDH12, acting in an oxidative and reductive capacity, depending on the cofactor available (NADP+ or NADPH, respectively).
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Московский государственный университет им. Ломоносова
Московский государственный университет им. Ломоносова
