Salt Inducible Kinase 3 (SIK3)

SIK3, Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. AMPK subfamily. Contains 1 protein kinase domain. Contains 1 UBA domain. Activated by phosphorylation on Thr-163 by STK11 in complex with STE20-related adapter-alpha (STRAD alpha) pseudo kinase and CAB39.In Drosophila and C. elegans, signal transduction pathways initiated by the activation of receptor-protein tyrosine kinases can mediate developmental fate decisions. One, designated Hek2, encodes the mouse ortholog of human HEK2, a member of the eph receptor protein tyrosine kinase gene family. The other, designated msk (myocardial Snf1-like kinase), encodes a putative protein serine/threonine kinase most similar to the yeast protein Snf1, which is involved in the response to nutritional stress.