Short Chain Dehydrogenase/Reductase Family 9C, Member 7 (SDR9C7)

Human SDRO encodes a 313-amino acid protein that shares 83% sequence identity with the mouse protein. Northern blot analysis on both mouse and human tissues revealed that SDRO is highly expressed in liver, with expression in mouse liver as early as embryonic day 7. A single 1.6-kb transcript is present in human tissues, whereas 4 transcripts are present in mouse tissues.SDRO does not have retinoid, 3-alpha-, 17-beta- or 11-beta-hydroxysteroid dehydrogenase activities. They suggested that SDRO may catalyze the metabolism of another class of nuclear receptor ligands, or may regulate metabolism by binding substrates or products, or by serving as a regulatory factor.