Sialyltransferase 1 (SIAT1)

SIAT1 is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein, which is normally found in the Golgi but which can be proteolytically processed to a soluble form, is involved in the generation of the cell-surface carbohydrate determinants and differentiation antigens HB-6, CDw75, and CD76. This protein is a member of glycosyltransferase family 29. Three transcript variants encoding two different isoforms have been found for this gene.A 4.7-kb ST6N transcript was expressed in nearly all tissues examined, with highest expression in liver, followed by kidney, spleen, thymus, prostate, and peripheral blood leukocytes. Several smaller transcripts were also detected in liver. Little to no expression was detected in pancreas, testis, and colon.