Sialyltransferase 7D (SIAT7D)
Английские синонимы
ST6GALNAC4; SIAT3C; ST6GALNACIV; ST6-N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 4; Alpha-N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 4
ST6GALNAC4 is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates.The encoded protein prefers glycoproteins rather than glycolipids as substrates and shows restricted substrate specificity, utilizing only the trisaccharide sequence Neu5Ac-alpha-2,3-Gal-beta-1,3-GalNAc. In addition, it is involved in the synthesis of ganglioside GD1A from GM1B. The encoded protein is normally found in the Golgi apparatus but can be proteolytically processed to a soluble form. This protein is a member of glycosyltransferase family 29. Transcript variants encoding different isoforms have been found for this gene.
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Московский государственный университет им. Ломоносова
Московский государственный университет им. Ломоносова
