TBK1 Binding Protein 1 (TBKBP1)

TBKBP1 is an adaptor protein that binds to TBK1 and is part of the interaction network in the TNF /NFKB pathway.The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. By searching for sequences with the potential to encode large proteins expressed in brain, Nagase et al. (1998) identified a cDNA encoding KIAA0775. The predicted protein contains 615 amino acids. RT-PCR analysis detected ubiquitous expression, with highest levels in ovary, followed by testis, brain, heart, lung, smooth muscle, kidney, and liver. The International Radiation Hybrid Mapping Consortium mapped the TBKBP1 gene to chromosome 17 (WI-14964).