Threonine Synthase Like Protein 2 (THNSL2)

Donini et al. (2006) searched sequence databases to identify proteins that encode possible threonine synthases (TS) and identified 2, which they designated TSH1 and TSH2, in several species, including humans and mice. Alternative splicing results in several deduced human TSH2 proteins, the longest of which contains 405 amino acids. EST database analysis indicated expression of both TSH1 and TSH2. In mouse, TSH2 transcripts are most abundant in the kidney and liver, whereas TSH1 transcripts are mainly seen in the brain and endocrine glands. The mouse TSH2 protein is 38% identical to S. cerevisiae threonine synthase.Donini et al. (2006) determined that TSH2 contains 7 introns in humans and mice. Human TSH2 appears to undergo differential splicing, producing several possible proteins.