Transmembrane Protein With Metallophosphoesterase (TMPPE)

TMPPE Belongs to the metallophosphoesterase superfamily. This domain is found in a diverse range of phosphoesterases, including protein phosphoserine phosphatases, nucleotidases, sphingomyelin phosphodiesterases and 2"""-3""" cAMP phosphodiesterases, as well as nucleases such as bacterial SbcD or yeast MRE11. The most conserved regions in this domain centre around the metal chelating residues.Bioinformatic Analysis for Identification of ICC/CpdA-like Proteins—The metallophosphoesterase superfamily encompasses a large number of protein sub-families that have in common a core seven-residue bimetal binding active site that catalyzes the hydrolysis of various phospho-, mono-, and diester substrates. The Pfam data base of protein families groups all these proteins by a single hidden Markov model built on 332 seed sequences.