Tubulin Tyrosine Ligase Like Protein 5 (TTLL5)

TTLL5 is a glucocorticoid receptor (GCCR) coregulator that interacts with coactivators TIF2 (NCOA2) and SRC1 (NCOA1).The deduced 1,226-amino acid protein shares 84% amino acid identity with its rat homolog.The deduced 1,277-amino acid protein has a calculated molecular mass of 143 kD and the C-terminal 705 amino acids share 83.3% identity to the putative mouse ortholog. TTLL5 contains an N-terminal TTL domain, a C-terminal coactivator interaction domain, and 3 C-terminal receptor interaction domains. Northern blot analysis of human tissues detected a 4.6-kb transcript with high expression in heart and skeletal muscle and low expression in placenta, lung, small intestine, kidney, brain, liver, spleen, thymus, and peripheral blood leukocytes. TTLL5 localized to the cytoplasm and nucleus.