UDP-Glucose Glycoprotein Glucosyltransferase 2 (UGGT2)

UDP-glucose:glycoprotein glucosyltransferase (UGT) is a soluble protein of the endoplasmic reticulum (ER) that selectively reglucosylates unfolded glycoproteins, thus providing quality control for protein transport out of the ER.By database searching with the HUGT1 sequence, Arnold et al. (2000) identified a homologous sequence, which they designated HUGT2. The assembled full-length HUGT2 cDNA encodes a deduced 1,516-amino acid protein that shares 55% sequence identity with HUGT1. HUGT2 has a predicted ER-targeting signal sequence, a putative ER retrieval signal, and 4 putative N-glycosylation sites. Northern blot analysis detected a 5.1-kb HUGT2 transcript in pancreas, heart, brain, placenta, lung, liver, skeletal muscle, and kidney. Arnold et al. (2000) noted that HUGT1 and HUGT2 differ slightly in their tissue distribution.