Ubiquitin Conjugating Enzyme E2G (UBE2G)

Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. UBE2G1 encodes a member of the E2 ubiquitin-conjugating enzyme family and catalyzes the covalent attachment of ubiquitin to other proteins. The protein may be involved in degradation of muscle-specific proteins.The cDNA encodes a deduced 170-amino acid protein. The predicted peptide product shares 74% sequence identity with UBC7 of C. elegans, a high degree of homology with UBC7s of other species, and significant homologies with other subgroups of UBCs. Northern blot analysis revealed strong expression of transcripts of 3 sizes in skeletal muscle. Weak expression was observed in 15 other tissues examined.