Ubiquitin Protein Ligase E3 Component N-Recognin 5 (UBR5)

UBR5 encodes a progestin-induced protein, which belongs to the HECT family. The HECT family proteins function as E3 ubiquitin-protein ligases, targeting specific proteins for ubiquitin-mediated proteolysis. This gene is localized to chromosome 8q22 which is disrupted in a variety of cancers. This gene potentially has a role in regulation of cell proliferation or differentiation.The deduced 2,799-amino acid protein contains 2 putative nuclear localization signals, a region sharing homology with polyadenylate-binding proteins, and a C-terminal HECT domain, which contains a conserved cysteine that binds ubiquitin via a thioester linkage. Northern blot analysis detected a 9.5-kb transcript in all tissues examined. RNA dot blot analysis found highest expression in testis, followed by brain, pituitary, and kidney.