Ubiquitin Specific Peptidase 41 (USP41)
Английские синонимы
Putative ubiquitin carboxyl-terminal hydrolase 41; Deubiquitinating enzyme 41; Ubiquitin thioesterase 41; Ubiquitin-specific-processing protease 41
The C19 family of ubiquitin specific proteases (USPs) deserves a particular analysis due to its large size and extreme complexity.The catalog of rat USPs includes Usp4, Usp18, and Usp19 absent in the current genome assembly but experimentally verified, as well as Usp9y—the only protease gene reported to date in chromosome Y—the sequence of which is not yet available in rat. Analysis of rat USPs shows some interesting differences with their human and mouse counterparts. USP41 is also absent in rat and mouse but present in the human lineage.USP41 belongs to the peptidase C19 family. May recognize and hydrolyze the peptide bond at the C- terminal Gly of ubiquitin. Involved in the processing of poly- ubiquitin precursors as well as that of ubiquinated proteins.
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Московский государственный университет им. Ломоносова
Московский государственный университет им. Ломоносова
