Ubiquitin Specific Peptidase Like Protein 1 (USPL1)

USPL1  is a 1,092 amino acid protein that exists as multiple alternatively spliced isoforms and is encoded by a gene which maps to human chromosome 13. Comprising nearly 4% of the human genome, chromosome 13 contains around 114 million base pairs and encodes over 400 genes. Chromosome 13 houses key tumor suppressor genes, including BRCA2 and RB1, which are associated with breast cancer susceptibility and retinoblastoma, respectively. Trisomy 13, also known as Patau syndrome, is deadly and the few who survive past one year suffer from permanent neurologic defects, difficulty eating and vulnerability to serious respiratory infections. Ubiquitin-specific proteases help to regulate many cellular processes by controlling the amount of the protein ubiquitin.