Vitamin K Epoxide Reductase Complex Subunit 1 Like Protein 1 (VKORC1L1)

By database searching with the sequence of VKORC1 as query, Rost et al. (2004) identified VKORC1L1. The deduced 176-amino acid protein shares 50% identity with VKORC1 and approximately 97% identity with mouse and rat Vkorc1l1. Rost et al. (2004) also identified a VKORC1L1 pseudogene.VKORC1 haplotype groups A and B explained approximately 25% of the variance in dose. Asian Americans had a higher proportion of group A haplotypes and African Americans a higher proportion of group B haplotypes. VKORC1 mRNA levels varied according to the haplotype combination. Thus the molecular mechanism of this warfarin dose response appears to be regulated at the transcriptional level.