WW Domain Containing E3 Ubiquitin Protein Ligase 2 (WWP2)

WWP2 encodes a member of the NEDD4-like protein family. The family of proteins is known to possess ubiquitin-protein ligase activity. The encoded protein contains 4 tandem WW domains. The WW domain is a protein motif consisting of 35 to 40 amino acids and is characterized by 4 conserved aromatic residues. The WW domain may mediate specific protein-protein interactions. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.The deduced 870-amino acid protein has a calculated molecular mass of 98.7 kD and shares 96% identity with human WWP2. Northern blot analysis detected 2 Wwp2 transcripts, with highest expression in testis, followed by spleen, kidney, and liver.