YOD1 OTU Deubiquinating Enzyme 1 Homolog (YOD1)

Deubiquitinating enzymes (DUBs) are proteases that specifically cleave ubiquitin linkages, negating the action of ubiquitin ligases. DUBA8 belongs to a DUB subfamily characterized by an ovarian tumor (OTU) domain.Kayagaki et al. (2007) identified ovarian tumor domain (OTU)-containing protein 2 (OTUD2) in a small interfering RNA (siRNA)-based screen for OTU deubiquitinating enzyme (DUB) family members. The 6,265-basepair mRNA contains an open reading frame (ORF) predicting a 348-amino acid protein. In addition to an OTU domain, the protein includes a zinc finger (ZNF) C2H2 domain.The YOD1 gene maps to chromosome 1q32.1.