tRNA Methyltransferase 10 Homolog A (TRMT10A)

The RNA methyltransferase family of proteins catalyze the transfer of a methyl group from a donor to an RNA acceptor. Via their ability to modify RNA, RNA methyltransferase proteins play an important role in cell growth and signaling pathways and may be involved in tumor development and progression. The RNA (guanine-9-) methyltransferase domain containing proteins (namely RG9MTD1, RG9MTD2 and RG9MTD3) are probable RNA methyltransferases that may play a role in RNA modification. Due to their involvement in RNArelated pathways, the RG9MTD proteins may be associated with methylation events that lead to carcinogenesis. While both RG9MTD1 and RG9MTD2 exist as one known isoform, RG9MTD3 is expressed as three isoforms produced by alternative splicing events.