tRNA Methyltransferase 2 Homolog A (TRMT2A)

Htf9c has a putative N-terminal nuclear targeting signal and a C-terminal domain similar to yeast and bacterial nucleic acid-modifying enzymes.mouse Htf9c and Ranbp1 were divergently transcribed from a bidirectional promoter. Expression of both genes was activated upon entry into the cell cycle, peaked in S phase, and was downregulated during completion of the cell cycle. The bidirectional promoter was downregulated in both orientations in arrested cells. Activation of the promoter was specific, resulting in more restricted Htf9c expression and a sharper peak of Htf9c expression in S phase compared with Ranbp1 expression. A region containing an E2f site was important for cell cycle control of Htf9c, and a common region containing sites for Sp1 and E2f contributed to activation in both orientations.