Complement Factor H Related Protein 2 (CFHR2)

CFHR2 encodes a serum protein structurally and immunologically related to complement factor H (CFH). Skerka et al. (1995) isolated and characterized the CFHR2 gene from a YAC library.Skerka et al. (1995) determined that the CFHR2 gene contains 5 exons and spans about 7 kb of genomic DNA.Skerka et al. (1995) demonstrated that the CFHR2 gene and the gene for the beta subunit of coagulation factor XIII (F13B) are located in the same 165-kb YAC DNA. Thus, the 3 structurally related genes F13B, CFHR2, and CFH are linked on chromosome 1 in the RCA (regulators of complement activation) gene cluster.The 5 factor H-related proteins have been identified and shown to be encoded by 5 genes, CFHR1, CFHR2, CFHR3 , CFHR4, and CFHR5, all closely linked to the CFH gene on chromosome 1q31-q32.1