Fc Receptor Like Protein A (FCRLA)

Receptors for the Fc fragment of IgG, or FCGRs , are cell surface glycoproteins of the Ig superfamily (IgSF). These receptors mediate phagocytosis of IgG-coated pathogens and promote activation of effector cells, leading to inflammatory responses and antibody-mediated cellular cytotoxicity. All FCGR genes map to human chromosome 1. Additional genes in this region, including FREB, encode FCGR homologs that are selectively expressed in B cells and may be implicated in B-cell development and lymphomagenesis.FCRLA contains a signal peptide, a hydrophilic peptide, 2 IgSF domains, and a C-terminal tail with a proline-rich region, a leucine-rich region, and an endoplasmic reticulum retention signal. FREB shares 64% identity with its mouse homolog and 29% identity with FCGR1A.