Germ Cell Associated Protein 2 (GSG2)

Haspin is transcribed from the opposite strand of intron 26 of the ITGAE gene.The deduced 798-amino acid protein contains a C-terminal kinase domain and a potential nuclear localization signal. The mouse and human haspin proteins share 66% amino acid identity overall, with 83% identity in the C-terminal portion. Northern blot analysis detected a major 3.0-kb transcript and a minor 4.0-kb transcript in testis. Expression was also detected in adult thymus and bone marrow, with weaker expression in adult prostate, intestine, lung, spleen, and lymph node. Haspin expression was detected in fetal liver, skin, kidney, and small intestine, and in all proliferating cell lines tested, particularly in B- and T-cell lines. Expression was not detected in nonproliferating cells.