Plasminogen Activator Inhibitor 1 RNA Binding Protein (SERBP1)

The deduced 387-amino acid human protein does not contain an RNA recognition motif or a K homology domain, but it has other motifs frequently found in RNA-binding proteins, notably an RGG box, an RG-rich region, and an arg-rich region. It also contains a putative protein kinase A phosphorylation site at ser74. PAIRBP1 shares several blocks of conserved sequence with proteins from Arabidopsis, Drosophila, chicken, mouse, and rat.PAIRBP1 binds to the cyclic nucleotide-responsive element of rat Pai1 in a concentration-dependent manner. By mutation analysis, they determined that PAIRBP1 interacts primarily with the adenine-rich region of the response element.