Plasminogen Like Protein A (PLGLA)

The deduced 96-amino peptide has a signal sequence followed by a 77-amino acid stretch that is identical to the N terminus of plasminogen (PLG) and differs from the homologous PRGB sequence at only 4 positions. Northern blot analysis using a probe that did not differentiate between PRGA and PRGB detected PRG only in liver and in a lymphoblastic leukemia cell line. Kida et al. (1997) characterized the 5-prime flanking region of the human PLGLA gene and found 3 TATA boxes 550 to 600 bp upstream of the transcription initiation site, a TATA-like sequence (TGTAA) at position -16, and putative binding sites for several transcription factors. The 1.1-kb 5-prime flanking sequence directed basal liver-specific expression in HepG2 cells, and deletion analysis identified 2 negative elements in the PLGLA promoter.