Sprouty Homolog 1 (SPRY1)

Spry mutations in Drosophila cause excessive branching. The spry protein is an antagonist of fibroblast growth factor (FGF) signaling that patterns apical branching of the Drosophila airways. In wildtype embryos, the Branchless FGF protein induces secondary branching by activating the Breathless FGF receptor near the tips of growing primary branches.A partial sequence of the human SPRY1 gene was identified.mouse Spry1 transfected into COS-1 cells was expressed as a cytosolic protein. Upon EGF stimulation, Spry1 translocated to membrane ruffles. Deletion analysis of human SPRY2 identified the translocation domain as a highly conserved 105-amino acid C-terminal domain.