Sprouty Homolog 3 (SPRY3)

Hacohen et al. (1998) found that the Drosophila sprouty gene encodes a novel cysteine-rich protein that defines a new family of putative signaling molecules that may similarly function as fibroblast growth factor antagonists in vertebrate development.  By amino acid homology searches of databases, Hacohen et al. (1998) identified and cloned 3 different human homologs, SPRY1, SPRY2, and SPRY3, of the Drosophila sprouty gene. A partial sequence of the human SPRY3 gene was identified. In their determination of the DNA sequence of the human X chromosome, Ross et al. (2005) demonstrated that the SPRY3 gene is located on the X chromosome in the second pseudoautosomal region (PAR2) at the telomeric end of the long arm. A homolog is located on the Y chromosome.