Thioredoxin Like Protein 4B (TXNL4B)

DLP, a novel Dim1 family protein implicated in pre-mRNA splicing and cell cycle progression. In eukaryotes, primary transcripts undergo a splicing process that removes intronic sequences by a macromolecular enzyme known as the spliceosome. This protein has 38% amino acid sequence identity with and is evolutionally related to yeast Dim1 protein. DLP is required for S/G(2) transition. DLP functions in cell nucleus and interacts with the U5-102-kDa protein subunit of the spliceosome, and blocking DLP protein activity led to an insufficient pre-mRNA splicing, suggesting that DLP is yet another protein component involved in pre-mRNA splicing. DLP is implicated in not only cell cycle progression but also in a more specific molecular process such as pre-mRNA splicing.