Thromboxane Receptor (TP)

The thromboxane receptor (TP) is a protein on the surface of cells in the endothelium of blood vessels and in the placenta which interacts with the eicosanoid lipid thromboxane. It is a G-protein coupled receptors coupled to the G protein Gq.The gene responsible for the thromboxane receptor, TBXA2R is found on chromosome 19 and spans 15 kilobases.Thromboxane is a potent stimulator for platelet aggregation and clot formation and also plays a role in vascular tone. The thromboxane receptor is a member of the family of G protein-coupled receptors. Mutation of the receptor can lead to a bleeding disorder.