Vascular Endothelial Zinc Finger Protein 1 (VEZF1)

Transcriptional regulatory proteins containing tandemly repeated zinc finger domains are thought to be involved in both normal and abnormal cellular proliferation and differentiation. ZNF161 is a C2H2-type zinc finger protein .Koyano-Nakagawa et al. (1994) cloned ZNF161 from a human Jurkat T-cell cDNA library using a CT/GC-rich sequence as probe. ZNF161 encodes a deduced 516-amino acid protein with a calculated molecular mass of about 56 kD. The predicted sequence contains 4 potential N-glycosylation sites and 6 C2H2-type zinc finger motifs. ZNF161 shares 48% sequence homology with the zinc finger protein MAZ. Northern blot analysis and RT-PCR demonstrated ubiquitous expression of 4.0- and 4.8-kb ZNF161 transcripts in all human tissues and cell lines tested.