Retinol Dehydrogenase 1 (RDH1)

Mouse rdh1 encodes retinol dehydrogenase type 1 (RDH1), a short-chain dehydrogenase, which recognizes as substrates all-trans-retinol, 9-cis-retinol, 5α-androstan-3,17-diol and 5α-androstan-3-ol-17-one. RDH1 is the most efficient known mouse short-chain dehydrogenase that catalyzes dehydrogenation of all-trans-retinol, and contributes to a reconstituted path of all-trans-retinoic acid biosynthesis, when coexpressed in reporter cells with any one of three retinal dehydrogenases. Rdh1 shows widespread, if not ubiquitous, mRNA expression in the mouse beginning no later than embryo day 7. Rdh1 consists of four exons and three introns and spans 14412 bp. Rdh1 is a single copy gene that maps to chromosome 10D3 with rdh5–9, but no known disorder maps precisely to rdh1. Rdh1 has three transcription start sites in kidney and one start site in liver.