Selenoprotein V (SELV)

Selenoprotein V (SelV) is a mammalian selenoprotein encoded on chromosome 19. SelV is a globular protein that occurs in the seminiferous tubules of the testes. Protein calculator program revealed that the molecular weight of SelV in human is about 37 kDa.Human SelV is a basic protein with isoelectric point of 9.65. SelV contains 5 exons, where the selenocysteine (sec) residue was predicted to be in exon 2. SECISearch 2.19 program revealed that the selenocysteine insertion sequence (SECIS) element belongs to type I structure. SelV contains three domains: The N-terminal domain is proline-rich; the second domain is the hydrophobic domain containing 20 amino acid residues as well as the selenocysteine residue; and the C-terminal domain which is rich in glutamate and lysine.