T-Cell Receptor Gamma (TCRg)

TCRG locus comprises 2 constant region genes separated by 16 kb and that these 2 genes can undergo rearrangements, deletion of the C-gamma-1 gene accompanying the rearrangements in the C-gamma-2 gene. These rearrangements have been observed in all T-cell types studied, providing evidence that the TCRG gene is an excellent marker of clonality for T-cell leukemias and lymphomas.The product of the rearranged gamma locus is the gamma chain, which is expressed, along with the delta chain, at the surface of a subset of T lymphocytes.the C-gamma-1 gene has 3 exons, whereas the C-gamma-2 gene has 4 exons including a duplicated second exon. The exon 2 of C-gamma-1 has a cysteine residue thought to be involved in the interchain disulfide bridge, whereas the 2 duplicated exons of C-gamma-2 have lost the cysteine residue.