Transmembrane Protease, Serine 8 (TMPRSS8)

TMPRSS8 Belongs to the peptidase S1 family. Contains 1 peptidase S1 domain. Expressed primarily in distal gut. Selectively cleaves synthetic peptide substrates of trypsin. Activates the epithelial sodium channel ENaC.This group of serine proteases belong to the MEROPS peptidase family S1 (chymotrypsin family, clan PA(S))and to peptidase family S6 (Hap serine peptidases).The chymotrypsin family is almost totally confined to animals, although trypsin-like enzymes are found in actinomycetes of the genera Streptomyces and Saccharopolyspora, and in the fungus Fusarium oxysporum. The enzymes are inherently secreted, being synthesised with a signal peptide that targets them to the secretory pathway. Animal enzymes are either secreted directly, packaged into vesicles for regulated secretion, or are retained in leukocyte granules .