ADP Ribosylation Like Factor 6 Interacting Protein 1 (ARL6IP1)

ARL6IP1 was found to be identical to mouse Arl6-interacting protein-1, which had been identified by yeast 2-hybrid screening as a protein interacting with mouse ADP-ribosylation-like factor. The protein also showed significant homology with human KIAA0069, which had been identified. the deduced 203-amino acid human protein shares 96% sequence identity with mouse Arl6ip. Pettersson et al. (2000) detected high expression of Arl6ip in brain, bone marrow, thymus, and lung; low expression in liver, kidney, and spleen; and no expression in heart. Immunofluorescence microscopy showed that mouse Arl6ip is predominantly localized to intracytoplasmic membranes, suggesting an involvement of the gene in protein transport, membrane trafficking, or cell signaling during hematopoietic maturation.