B-Cell CLL/Lymphoma 7A (Bcl7A)

Bcl7A is directly involved, with Myc and IgH, in a three-way gene translocation in a Burkitt lymphoma cell line. As a result of the gene translocation, the N-terminal region of the gene product is disrupted, which is thought to be related to the pathogenesis of a subset of high-grade B cell non-Hodgkin lymphoma. The N-terminal segment involved in the translocation includes the region that shares a strong sequence similarity with those of BCL7B and BCL7C. Two transcript variants encoding different isoforms have been found for this gene.B-cell CLL/lymphoma refers to a family of genes associated with certain types of lymphoma and leukemia.Although named for B-cell chronic lymphocytic leukemia, they can be associated with other malignancies.