B-Cell CLL/Lymphoma 7B (Bcl7B)

By EST database searching, screening of a liver cDNA library, and sequencing, they cloned a BCL7B cDNA encoding a deduced 202-amino acid protein that shows high homology to the BCL7A gene, which was cloned from a complex chromosomal translocation in Burkitt lymphoma cell lines. BCL7B is highly conserved from C. elegans to human, suggesting that it has been conserved through evolution.Jadayel et al. (1998) also cloned the BCL7B gene as well as the BCL7C gene. They determined that both encode proteins sharing 90% identity with the N-terminal 51 amino acids of BCL7A and suggested that the 3 genes are members of an evolutionarily conserved gene family.