CD3e Molecule Epsilon Associated Protein (CD3eAP)

Paf49 interacts with the polymerase I complex, specifically with Paf53 and Taf1a . Mutation analysis indicated that the N terminus of Paf49 interacts with Paf53 and Taf1a, and the C terminus may also contribute to a lesser extent to the interaction with Taf1a. In exponentially growing mouse fibroblasts, Paf49 colocalized with the ribosomal transcriptional activation factor Ubf within large discrete nucleoli. When cells were cultured in serum-restricted medium, some Paf49 dispersed into the nucleoplasm.the mouse polymerase I complex and cloned the 49-kD polypeptide, Paf49. By database analysis, they determined that Paf49 is the mouse homolog of human ASE1. The deduced human ASE1 protein contains 510 amino acids.