Complement Component 1, Q Subcomponent Like Protein 1 (C1qL1)

The deduced 258-amino acid human protein has a predicted molecular mass of 28.4 kD. C1QL1 has a C-terminal globular domain that shares homology with the C1q signature domain of C1q subunits and an N-terminal collagenous domain and a hydrophobic sequence. Dot blot analysis of human tissues detected C1QL1 in all specific brain regions examined as well as in adult kidney, lung, small intestine, appendix, heart, colon, bladder, uterus, prostate, stomach, and fetal brain, heart, and kidney. Immunofluorescence localized C1QL1 exclusively to clusters in the cytoplasm, likely to Golgi or endoplasmic reticulum. In situ hybridization of mouse brain detected highest expression in cerebellar Purkinje cells, the accessory and inferior olivary nucleus, the red nucleus, and the cortex.